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Acid Blockers for Constant Heartburn and Acid Reflux These drugs work by blocking just how much gastric acid you produce. Not as fast-acting as antacids, these acid blockers stay longer which enables them to work for a couple of hours at a time, says the AGA. Over-the-counter acid blockers include Axid, Pepcid, Tagamet, and Zantac. These brands are also available in prescription strength if the more mild forms don't bring enough relief. constant heartburn These drugs work by blocking a kind of histamine manufactured by your stomach, which in turn blocks acid production. These histamine blockers are generally taken twice daily, 30 to 60 minutes before eating in order to be effective. They're best used as a form of protection, as opposed to a sudden, fast relief of symptoms.